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目的研究呋塞米雾化作为AECOPD辅助治疗方法的效果。方法将120例AECOPD病人随机、双盲分成对照组与治疗组。在常规治疗的基础上,对照组给予4 ml生理盐水雾化吸入,治疗组给予4 ml呋塞米雾化吸入。比较患者吸药前和吸药后1 h呼吸困难程度、FEV1、动脉血气分析、血压、心率和呼吸频率的变化。结果两组病人在雾化后各项实验指标都有所改善,但呋塞米吸入组患者FEV1、呼吸困难程度、pH、平均血压、PaO2、呼吸频率和心率改善程度较对照组显著(P<0.05)。结论呋塞米雾化作为AECOPD病人的辅助治疗是有效的。
Objective To study the effect of furosemide atomization as an adjuvant treatment of AECOPD. Methods 120 AECOPD patients were randomly divided into control group and treatment group. On the basis of routine treatment, the control group was given 4 ml saline inhalation, the treatment group given 4 ml furosemide inhalation. The changes of dyspnea, FEV1, arterial blood gas analysis, blood pressure, heart rate and respiratory rate were compared before and 1 h after inhalation. Results After the atomization, the experimental indexes of both groups were improved. However, the improvement rate of FEV1, degree of dyspnea, pH, mean blood pressure, PaO2, respiratory rate and heart rate in the inhaled furosemide group were significantly higher than those in the control group (P < 0.05). Conclusions Furosemide nebulization is an adjunctive therapy for AECOPD patients.