The Formamidine Amitraz as a Hyperglycemic α-Agonist in Worker Honeybees(Apis mellifera mellifera L.

• 作 者: P.CASCINO M.NECTOUX G.GUIRAUD M.BOUNIAS
• 机 构: Laboratory of Biochemistry INRA-Avignon,B.P.91,F84140 Montfavet,France,Laboratory of Biochemistry,IN
• 出 处: Biomedical and Environmental Sciences
• 发表日期: 1989年02期
• 关键词: mellifera in Vivo Apis Worker administration pesticide likely suppressed approx

Intra-abdominal injection of amitraz(0.25 nmol per honeybee,i.e.,approx 2.3 nmol/g)toemerging worker bees,in vivo,led to a significant hypertrehalosemia(300-400%)followed by ahyperglucosemia(≈600%).Maxima were reached at 0.5 and 2h,respectively.A strong negativecorrelation between glucosemia and trehalosemia appeared after injection of pure phentolamine(1 nmol per bee),suggesting stimulation of trehalase activities.Simultaneous administration ofthe α-blocker at≥0.25 nmol per individual suppressed the hyperglycemic response of amitraz.The formamidine pesticide thus likely acts on the honeybee α-aminergic system.1989 AcademicPress,Inc.

Intra-abdominal injection of amitraz (0.25 nmol per honeybee, ie, approx 2.3 nmol / g) toemerging workers bees, in vivo, led to a significant hypertrelose (300-400%) followed by ahyperglucosemia (≈600%). at 0.5 and 2h, respectively.A strong negativecorrelation between glucosemia and trehalosemia was caused by injection of pure phentolamine (1 nmol per bee), suggesting stimulation of trehalase activities. Simultaneous administration of the α-blocker at ≧ 0.25 nmol per individual suppressed the hyperglycemic response of amitraz. The formamidine pesticide thus likely acts on the honeybee α-aminergic system. 1989 Academic Press, Inc.