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目的:观察子宫动脉灌注栓塞化疗治疗早期巨块型宫颈癌的效果,并对其机制进行简要分析。方法:选择52例早期宫颈癌患者,采用完全随机的方式选择29例患者为灌注化疗组,在手术前行1-2疗程的子宫动脉灌注栓塞化疗;其余23例患者为对照组,行手术治疗。记录两组的临床疗效及不良反应。结果:灌注化疗组总有效率为88.5%,5例出现下腹部疼痛,2例患者出现恶心呕吐,13例出现一过性白细胞下降,手术过程中失血量较对照组少(P<0.05),术后有4例淋巴结阳性,1例宫旁组织阳性,对照组中有8例淋巴结阳性,9例宫旁组织阳性,1例患者出现阴道切缘阳性,各项指标均低于对照组(P<0.05)。结论:子宫动脉灌注栓塞化疗可以明显缩小早期巨块型宫颈癌病灶,提高手术成功率和患者预后。
Objective: To observe the effect of uterine arterial infusion chemoembolization in the treatment of early massive cervical cancer, and to analyze its mechanism briefly. Methods: Totally 52 patients with early stage cervical cancer were enrolled in this study. Totally 29 patients were selected as perfusion chemotherapy group in a completely randomized manner. Uterine artery embolization and chemoembolization were performed 1-2 weeks prior to surgery. The remaining 23 patients were treated by surgery . Record the clinical efficacy and adverse reactions in both groups. Results: The total effective rate was 88.5% in perfusion chemotherapy group, 5 cases of lower abdominal pain, 2 cases of nausea and vomiting, 13 cases of transient leukopenia, blood loss during operation less than the control group (P <0.05) There were 4 positive lymph nodes and 1 paracarcinoma postoperatively. There were 8 positive lymph nodes in the control group and 9 positive palatoplasms in the control group. Positive margins of the vagina were found in 1 patient, and all the indexes were lower than those in the control group (P <0.05). Conclusion: Uterine arterial infusion chemotherapy can significantly reduce the early giant cervical lesions, improve the success rate of surgery and prognosis.