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1998年,Tatemoto等应用反向药理学方法在牛胃组织提取物中发现了G蛋白耦联受体-血管紧张素Ⅰ型受体相关的受体蛋白(ptctative receptorprotein related to the angiotensin receptor,AT1,APJ)的内源性配体Apelin,此后Apelin-APJ系统成为研究的热点。Apelin-APJ在人体多种组织中广泛存在,具有广泛的生物学效应。研究表明Apelin-APJ在肺组织中的联合表达水平最高,在肺组织中具有调节循环稳态、内皮增殖,调节免疫及氧化损伤,并具有抗炎及抗病毒等作用,其参与了肺动脉高压、肺血栓栓塞症、急性肺损伤和(或)急性呼吸窘迫综合征(acute lung injury/acute respiratory distresssyndrome,ALI/ARDS)及肺癌等肺部疾病的发病过程,本文就近年Apelin与上述肺部疾病的研究进行回顾和综述。
In 1998, Tatemoto et al. Used reverse pharmacological methods to find G protein-coupled receptor-related receptor of angiotensin receptor (AT1, APJ) endogenous ligand Apelin, after which Apelin-APJ system has become a hot spot. Apelin-APJ is widespread in many human tissues and has a wide range of biological effects. Studies have shown that Apelin-APJ expression in the lung tissue the highest level in the lung tissue with regulation of circulatory homeostasis, endothelial proliferation, regulate immune and oxidative damage, and has anti-inflammatory and anti-viral effect, which is involved in pulmonary hypertension, Pulmonary thromboembolism, acute lung injury and / or acute respiratory distress syndrome (ALI / ARDS) and lung cancer and other lung disease pathogenesis, this article in recent years, Apelin and lung disease The study was reviewed and reviewed.