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钙拮抗剂通过消除体循环阻力血管的钙依赖性张力过高和收缩过强而发挥抗高血压作用。但并非所有的钙拮抗剂都有降压作用。 Godfraind汇编的“钙拮抗剂”包括氟桂嗪、桂利嗪、利多氟嗪、罂粟碱、吲哚美辛、新霉素、地苯那明(Dibenamine)、苯苄胺、丙米嗪、地昔帕明、氯丙嗪、氟哌啶醇、二氮嗪、舒洛地尔(Suloctidil)、局部麻醉药(例如普鲁卡因、丁卡因、地布卡因)以及氨利酮(Amrinone)等。其中多数除主要药理作用外,又具有非特异性钙拮抗作用。作者发现,以钙拮抗作用为主,最有代表
Calcium antagonists exert antihypertensive effects by eliminating the calcium-dependent hypertonia and contractions of vascular resistance vessels. But not all calcium antagonists have antihypertensive effects. The “calcium antagonists” compiled by Godfraind include flunarizine, cinnarizine, lidiproflazine, papaverine, indomethacin, neomycin, Dibenamine, benbenzamide, imipramine, (Eg, procaine, tetracaine, dibucaine), and Amrinone )Wait. Most of them in addition to the main pharmacological effects, but also has a non-specific calcium antagonism. The authors found that the main role of calcium antagonists, the most representative