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现在已很清楚炎症细胞对肿瘤的发展有很大影响,在早期瘤形成过程中,炎症细胞是很强的肿瘤促进因子,它们营造了一个有利肿瘤生长的环境,致成细胞中基因的不稳定性,并且促使产生血管。炎症细胞及其产生的趋化因子和细胞因子可影响肿瘤的整体结构,调节它们在微环境中的生长、迁移和细胞分化,这种微环境是由癌细胞、成纤维细胞和内皮细胞所形成的。在肿瘤生长过程的后阶段,瘤细胞也借用炎症的各种机制,例如选择素-配体(selectin-ligand)相互反
It is now clear that inflammatory cells have a significant impact on the development of tumors. In the early stage of neoplasia, inflammatory cells are potent tumor-promoting agents that create an environment conducive to tumor growth, resulting in the instability of genes in cells Sexual, and prompted the production of blood vessels. Inflammatory cells and their production of chemokines and cytokines can affect the overall structure of tumors, regulating their growth, migration and cell differentiation in the microenvironment formed by cancer cells, fibroblasts and endothelial cells of. In the later stages of tumor growth, tumor cells also borrow various mechanisms of inflammation, such as selectin-ligand,