葡萄糖耐量低减者的自然转归

• 作 者: G.Nijpels C.Popp-Snijders L.M.Bouter R.J.Heine 张木勋
• 机 构: Institute for Research in Extramural Medicine,Vrije Universteit,Amsterdam,The Netherlands.,Institute
• 出 处: The Chinese-German Journal of Clinical Oncology
• 发表日期: 1995年02期
• 关键词: 葡萄糖耐量 自然转归 NIDDM 血浆葡萄糖 随机采样 胰岛素抵抗 中小城镇 空腹胰岛素 糖基化血红蛋白 其年

本研究目的旨在认识葡萄糖耐量低减(IGT)者发展成糖尿病的危险因素。在荷兰Hoorn中小城镇中随机采样年龄在50～74岁者的葡萄糖耐量试验(OGTT),糖耐量采集(WHO标准)2次OGTT平均值。在IGT者中70％(n=169)参与此项研究,接受随访的人每2周分别重复一次OGTT,平均随访时间为22月(13～36月)。IGT转变为NIDDM(非胰岛素依赖型糖尿病)的指征是平均2小时血浆葡萄糖≥11.1mmol/L,其年发病率为16.4％(95％CI4,5～39名)。转变的基础指数(平均±SD n=49)

The purpose of this study was to identify risk factors for developing impaired glucose tolerance (IGT) into diabetes. Randomly sampled glucose tolerance test (OGTT) and glucose tolerance test (WHO standard) 2-time OGTT average for individuals aged 50-74 years in Hoorn, Netherlands. Of the IGT patients, 70% (n = 169) participated in the study, and those on follow-up repeated OGTT every two weeks with an average follow-up of 22 months (13-36 months). An indication of the conversion of IGT to NIDDM (non-insulin dependent diabetes) is an average of 2 hours of plasma glucose ≥11.1 mmol / L with an annual incidence of 16.4% (95% CI, 4,5 to 39). The basal index of change (mean ± SD n = 49)