含吩噻嗪基团8-羟基喹啉的合成及其DPPH清除自由基活性(英文)

• 作 者: 童碧海 梅群波 倪现花 张千峰
• 机 构: 安徽工业大学分子工程与应用化学研究所,南京邮电大学,江苏省有机电子与信息显示重点实验室和先进材料研究所,
• 出 处: 安徽工业大学学报(自然科学版)
• 发表日期: 2010年01期
• 关键词: 羟基喹啉 DPPH 吩噻嗪 自由基活性 氧化活性 抗氧化剂 自由基清除率 苦基 scavenging 紫外吸收光谱

报道了一种新颖的带吩噻嗪基团8-羟基喹啉衍生物抗氧化剂,该化合物通过5-氯甲基-8-羟基喹啉与吩噻嗪在有机碱三乙胺存在下的反应而制备,并通过核磁共振谱、红外光谱和元素分析进行了表征,其羟基扫描活性通过可见-紫外吸收光谱进行了测定,抗氧化活性用2,2-二苯基-1-苦基肼(DPPH)模型系统进行了测定。与叔丁对氧酚相比,5-吩噻嗪甲基-8-羟基喹啉表现出了很高的抗氧化活性,当其质量浓度分别为0.2,0.5,0.8和1.0mg/mL时,相应的最大自由基清除率分别37.55%,76.16%,83.94%和84.04%。

Reported a novel phenothiazine group 8-hydroxyquinoline derivative antioxidant by reacting 5-chloromethyl-8-hydroxyquinoline with phenothiazine in the presence of an organic base triethylamine , And characterized by 1H-NMR, IR and elemental analysis. The hydroxyl radical scavenging activity was measured by visible-UV absorption spectroscopy. The antioxidant activity was measured with 2,2-diphenyl-1-picrylhydrazide DPPH) model system. 5-Phenothiazine methyl-8-hydroxyquinoline showed high antioxidant activity compared with tert-butyl-p-oxy-phenol, and when its mass concentration was 0.2, 0.5, 0.8 and 1.0 mg / mL, The corresponding maximum free radical scavenging rates were 37.55%, 76.16%, 83.94% and 84.04%, respectively.