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目的 :探讨长期口服足叶乙甙 (VP- 16 )及三苯氧胺 (TAM)方案治疗晚期肝癌的效果。方法 :对失去手术及介入治疗机会的 40例晚期肝癌分为两组。观察组 :口服 VP- 16 5 0 m g,每日 1次及 TAM2 0 mg,每日 2次 ,两药均应用 14天 ,休息 14天 ,为 1周期。对照组 :采用对症、支持、保肝等姑息性治疗。结果 :两组有效率 (CR+ PR)分别为2 6 .1%和 0 % (P<0 .0 5 )。观察组有效者中位生存 10 .8个月 ,进展者中位生存 3.5个月。对照组中位生存 3.0个月。观察组有效者生存质量及 KS评分均明显提高 ,主要毒副反应是脱发、骨髓抑制和胃肠道反应 ,均为轻度。结论 :长期口服 VP- 16及 TAM治疗晚期肝癌具有一定疗效 ,能提高患者生存质量 ,且无明显毒副反应
Objective : To investigate the long-term effects of oral epinephrine (VP-16) and tamoxifen (TAM) regimens on advanced liver cancer. Methods: Forty patients with advanced liver cancer who lost surgery and interventional treatment were divided into two groups. Observation group: oral VP-16 500 mg, once daily and TAM2 0 mg, 2 times daily, both drugs applied for 14 days, rest for 14 days, 1 cycle. Control group: Palliative treatment such as symptomatic, supportive and hepatic protection was adopted. Results: The effective rates of the two groups (CR+PR) were 26.1% and 0%, respectively (P<0.05). The median survival of the observation group was 10.8 months, and the median survival rate was 3.5 months. The median survival of the control group was 3.0 months. The quality of life and KS scores of the effective group in the observation group were significantly increased. The main toxicities were hair loss, bone marrow suppression, and gastrointestinal reactions, both of which were mild. Conclusion : Long-term oral administration of VP-16 and TAM for the treatment of advanced liver cancer has a certain effect, can improve the quality of life of patients, and no obvious side effects