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据Zhang Q 2013年7月8日(Proc Natl Acad Sci USA.2013 Jul 8.)报道,通过在酵母细胞中研究基因功能,宾州州立大学(Penn State University)的研究者研究发现,组蛋白的修饰可以控制是否一个基因被允许发挥功能,这对于维持基因的表达潜力非常重要,以便来确定未来细胞的行为。基因表达是任何生物活性细胞最重要的一个基础环节,基因表达的不同程序,甚至是拥有同样DNA的细胞,其都会表现出不同的细胞行为和功能;比如人类肌肉细胞和神经细胞拥有同样的DNA,但是其行为和功能并不一样;基因表达的错误调节会影响细胞的适合度并且引发疾病;基因表达趋于在细胞间表现出不同,错误调节是在一小类细胞中发生的,而且这些细胞随后也会发
According to Zhang Q, July 8, 2013 (Proc Natl Acad Sci USA. 2013 Jul. 8), researchers investigating Penn State University through the study of gene function in yeast cells reported that histone Modifications can control whether a gene is allowed to function, which is important to maintain the gene’s potential for expression in order to determine future cell behavior. Gene expression is the most fundamental part of any bioactive cell. Different programs for gene expression, even cells with the same DNA, exhibit different cellular behaviors and functions; for example, human muscle cells and nerve cells possess the same DNA , But behaves differently than they do; the misregulation of gene expression affects the fitness of a cell and triggers a disease; the expression of a gene tends to show differences among cells, and misregulation occurs in a small group of cells, and these Cells will also be sent later