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目的回顾分析胶质瘤术后患者放射治疗的疗效,探讨影响放射治疗胶质瘤的预后因素。方法资料完整的胶质瘤患者67例,其中低分级39例,高分级24例,室管膜瘤4例。所有患者均进行了手术切除(其中全切术31例,次全切除术36例),手术后一月内接受60Coγ射线放射治疗。Kaplan-Meier法计算生存率,Cox比例风险模型进行预后的多因素分析。结果单因素分析显示,患者年龄<45岁、低分级胶质瘤、手术全切肿瘤者的1年,3年,5年生存率较高。多因素分析显示,年龄、病理分级、手术切除程度是独立预后因素。结论年龄、病理分级、手术切除程度是影响放射治疗胶质瘤的重要预后因素。
Objective To retrospectively analyze the curative effect of radiotherapy in patients with glioma after operation and to explore the prognostic factors of radiotherapy glioma. Methods Data of 67 patients with complete glioma, including 39 cases of low grade, high grade 24 cases, 4 cases of ependymoma. All patients undergone surgical resection (including total resection in 31 cases, subtotal resection in 36 cases), received 60Co γ-ray within a month after surgery. Kaplan-Meier method to calculate the survival rate, Cox proportional hazards model for prognosis of multivariate analysis. Results Univariate analysis showed that patients aged <45 years, low-grade gliomas, surgical total resection of the tumor at 1 year, 3 years, 5-year survival rate higher. Multivariate analysis showed that age, pathological grade, degree of surgical resection were independent prognostic factors. Conclusion Age, pathological grade and degree of surgical resection are important prognostic factors for radiotherapy of gliomas.