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目前认为外周血管阻力增加是原发性高血压重要的病理生理特点和血液动力学障碍。许多动物和临床研究表明,Ca~(2+)是决定平滑肌张力的主要离子,在动脉中层尤其平滑肌细胞内Ca~(2+)过多积聚可能是导致血管阻力增加、血压上升的原因之一。血管壁Ca~(2+)过量还可激活
It is currently believed that increased peripheral vascular resistance is an important pathophysiologic feature and hemodynamic disorder of essential hypertension. Many animal and clinical studies have shown that Ca2 + is the main ion that determines the tension of smooth muscle. Over Ca2 + accumulation in the middle artery, especially in smooth muscle cells may be one of the causes of increased vascular resistance and blood pressure . The excessive Ca ~ (2+) in the vascular wall can be activated