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目的 :探讨 2型糖尿病肾病与脂质代谢紊乱、胰岛素抵抗的关系。方法 :测定 4 2例 2型糖尿病肾病患者和 4 0例 2型糖尿病不伴肾损害患者的血脂、尿白蛋白排泄率 (UAER)、空腹血糖 (FPG)、空腹胰岛素 (FINS)等 ,并进行比较分析 ,胰岛素敏感指数 (ISI)采用改良胰岛素敏感指数公式计算。结果 :糖尿病肾病患者的FINS、甘油三脂 (TG)和载脂蛋白B(APOB)显著升高 ,ISI和载脂蛋白A1(APOAI)显著降低。结论 :脂质代谢紊乱及胰岛素抵抗与糖尿病肾病关系密切。
Objective: To investigate the relationship between type 2 diabetic nephropathy and lipid metabolism disorders and insulin resistance. Methods: The levels of serum lipids, urinary albumin excretion (UAER), fasting plasma glucose (FPG) and fasting insulin (FINS) were determined in 42 patients with type 2 diabetic nephropathy and 40 with type 2 diabetic patients without renal impairment. Comparative analysis, insulin sensitivity index (ISI) calculated using a modified insulin sensitivity index formula. Results: FINS, triglyceride (TG) and apolipoprotein B (APOB) in patients with diabetic nephropathy were significantly increased, and the levels of ISI and apolipoprotein A1 (APOAI) were significantly decreased. Conclusion: The disorders of lipid metabolism and insulin resistance are closely related to diabetic nephropathy.