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目的探讨生殖异常患者与外周血细胞染色体异常的关系,观察遗传因素在生殖异常患者的重要性。方法检测588例生殖异常患者外周血淋巴细胞染色体核型。结果 588例有不孕、不育、畸形、死胎、习惯性流产患者染色体检查出异常核型28例,其中3例为平衡易位携带者,2例inv(9),1例inv(4),1例t(1;19),1例+m ar,1例21ps+,1例22ps-,2例47,XXY,16例Y≥18号。结论不孕、不育、畸形、死胎、习惯性流产患者与染色体异常有关,与染色体多态性变化也有一定关联。
Objective To investigate the relationship between genital abnormalities and chromosomal aberrations in peripheral blood cells and to observe the importance of genetic factors in genital abnormalities. Methods 588 cases of genital abnormalities in patients with peripheral blood lymphocytes chromosome karyotype. Results Of the 588 patients with infertility, infertility, deformity, stillbirth and habitual abortion, 28 cases were detected abnormal chromosomes, of which 3 were carriers of balanced translocations, 2 inv (9), 1 inv (4) , 1 case of t (1; 19), 1 case of + m ar, 1 case of 21ps +, 1 case of 22ps-, 2 cases of 47, XXY, 16 cases of Y≥18. Conclusions Infertility, infertility, deformity, stillbirth and habitual abortion are related to chromosomal abnormalities and also to chromosome polymorphism.