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目的:分析乳腺癌患者化疗后的认知功能受损情况。方法:分别对50例乳腺癌化疗患者、50例乳腺癌非化疗患者、50例体检结果健康者行成套神经心理学量表评定,并分别设为观察组、对照组1、对照组2,比较三组的组被试神经心理学特症。结果:观察组1倒背测验、延迟记忆测验、再认回忆测验得分均低于另外两组,完成Stroop任务B、Stroop任务C、连线任务B所用时间均高于另外两组,比较差异具有统计学意义;三组顺背得分、即刻记忆得分、Stroop任务A完成所用时间、连线任务任务A完成所用时间、词汇流畅性测评分、蒙特利尔认知评估量表得分的比较差异无统计学意义,P>0.05。结论:乳腺癌患者行化疗治疗对认知功能的损害主要表现在对记忆力、注意力、执行力的改变上。
Objective: To analyze the cognitive impairment of patients with breast cancer after chemotherapy. Methods: Fifty cases of breast cancer chemotherapy, 50 cases of breast cancer non-chemotherapy patients and 50 cases of physical examination results were assessed by neuropsychological questionnaire, and were divided into observation group, control group 1, control group 2, comparison Three groups of subjects were tested neuropsychological features. Results: The scores of back test, delayed memory test and recall test in observation group 1 were lower than those in the other two groups. The time spent on completing Stroop task B, Stroop task C and connecting task B were higher than the other two groups Statistical significance; three groups Shun back score, instant memory score, the completion time of Stroop task A, connection task task A completion time, vocabulary fluency test score, Montreal Cognitive Assessment Scale score no significant difference , P> 0.05. Conclusion: The damage of cognitive function in patients with breast cancer treated with chemotherapy is mainly manifested in the change of memory, attention and executive ability.