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目的:探讨孕前BMI、孕20周前体重增长与妊娠期高血压疾病(HDP)的相关性,为HDP的治疗提供理论依据。方法:选取2012年1月~12月在北京市海淀区妇幼保健院住院分娩的产妇12 259名,收集其病历资料,采用多因素Logistic回归对相关因素进行分析。结果:孕前超重/肥胖者发生HDP的风险分别为孕前BMI正常者的2.6(2.1~3.1)和4.4(3.2~5.9)倍;孕20周前体重增长较多者发生HDP的风险是体重增长较少者的1.2(1.0~1.4)倍;孕前超重/肥胖者中孕20周前体重增长较少者HDP的发生风险低于体重增长较多者。结论:孕前超重/肥胖、孕20周前体重增长过多均是HDP的危险因素,与孕20周前体重增长较多相比,孕前超重/肥胖在HDP的发生中作用更强;减少孕20周前体重增长可在一定程度上降低孕前超重/肥胖者HDP的发生风险。
OBJECTIVE: To investigate the relationship between pre-pregnancy BMI, weight gain and gestational hypertension (HDP) before pregnancy 20 weeks, and to provide a theoretical basis for the treatment of HDP. Methods: Twelve to 259 mothers were hospitalized in Haidian District Maternal and Child Health Hospital of Beijing from January to December 2012. The medical records were collected and the multivariate logistic regression analysis was used to analyze the related factors. Results: The risk of HDP in pre-conception overweight / obesity was 2.6 (2.1-3.1) and 4.4 (3.2-5.9) times higher than those in pre-pregnancy BMI respectively. The risk of HDP with more body weight gain in 20 weeks before pregnancy was the weight gain Less than 1.2 (1.0 ~ 1.4) times; pre-conception overweight / obesity 20 weeks before pregnancy less weight HDP risk lower than those who gain weight more. CONCLUSIONS: Excessive weight / obesity before pregnancy and excessive body weight gain 20 weeks before pregnancy are all risk factors for HDP. Compared with more weight gain before pregnancy 20 weeks ago, pre-pregnancy overweight / obesity has a stronger role in HDP development and less pregnancy 20 Weight gain a week ago to a certain extent, reduce pre-pregnancy HDCP risk of overweight / obesity.