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目的：采用高效液相色谱法（ＨＰＬＣ），对８名男性健康志愿者顿服国产力康结核片（ｐａｓｉｎｉａｚｉｄｅ）与进口力排肺疾片（ｄｉｐａｓｉｃ）１２００ｍｇ后的药代动力学进行研究。方法：采用ＨｙｐｅｒｓｉｌＢＤＳＣ１８（１０μｍ４６×２５０ｍｍ）色谱柱，甲醇∶００２ｍｏｌＮａ２ＨＰＯ４＝５∶９５（ｐＨ７．４Ｖ∶Ｖ）为流动相，流速０８ｍｌ／ｍｉｎ，检测波长２５４ｎｍ进行测定。结果：力康结核片和力排肺疾片的主要动力学参数分别为：消除半衰期：Ｔ１／２６８２±０２５ｈ和６６６±０１７ｈ；峰浓度Ｃｍａｘ：８０３±０２６ｍｇ／ｍｌ和８０８±０３ｍｇ／ｍｌ；达峰时间Ｔｍａｘ：３３９±０１０ｈ和３７７±０３１ｈ；血药浓度－时间曲线下面面积为：１１８８２±１０２８ｍｇ／Ｌ．ｈ和１２１０７±１１６８ｍｇ／Ｌ．ｈ。结论：国产力康结核片与进口力排肺疾片的主要药动学参数基本相似。两者的相对生物利用度为９８１４％，属生物等效。
OBJECTIVE: To study the pharmacokinetics of 8 male volunteers after taking domestic lincomycin and imported dipasic 1200mg by high performance liquid chromatography (HPLC). Methods: The mobile phase was Hypersil BDSC18 (10μm46 × 250mm), methanol: 0.02molNa2HPO4 = 5:95 (pH7.4V:V), the flow rate was 0.8ml / min and the detection wavelength was set at 254nm. Results: The main kinetic parameters of Li Kang’s TB tablets and Li-Pao-Lung Tablets were: elimination half-life: T1 / 2682 ± 025h and 666 ± 017h; peak concentration Cmax: 803 ± 0 ‡ 26mg / ml and 8 08 ± 0 3mg / ml; peak time Tmax: 3 39 ± 0 10h and 3 77 ± 0 31h; plasma concentration - time curve under the area of 118 82 ± 1028mg / L. h and 12107 ± 1168 mg / L. h Conclusion: The main pharmacokinetic parameters of domestic Li Kangkang tablets and imported tablets of lung-lung disease are basically similar. The relative bioavailability of both was 98.14%, which is bioequivalent.