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目的观察52例多发伤患者弥散性血管内凝血的早期诊断及早期给予血小板、冷沉淀、凝血酶原复合物、血浆、肝素治疗的临床效果。方法对多发伤患者早期进行血小板计数、凝血功能、D-二聚体检查,对合并DIC的52例患者根据其血小板计数、凝血功能给予血小板、冷沉淀、凝血酶原复合物、血浆、肝素治疗并观察治疗后1天患者的血小板计数、凝血功能。结果治愈46例,死亡6例,治愈率88.5%。52例患者输注血小板、冷沉淀、凝血酶原复合物、血浆、肝素治疗后1天与输注前相比,患者的血小板计数明显增加,凝血酶原时间(PT)明显缩短,纤维蛋白原(Fbg)含量增加。结论对多发伤并发DIC患者早期输注血小板、冷沉淀、凝血酶原复合物、血浆、肝素等综合治疗可有效阻止DIC的继续发展,重建凝血机制,恢复机体功能。
Objective To observe the early diagnosis of disseminated intravascular coagulation in 52 patients with multiple trauma and the clinical effects of early administration of platelet, cryoprecipitate, prothrombin complex, plasma and heparin. Methods Thrombocytopenia, coagulation and D-dimer examination were performed in patients with multiple traumatic injuries. Twenty-two patients with DIC were treated with platelet, cryoprecipitate, prothrombin, plasma and heparin according to their platelet count, coagulation function The patients’ platelet count and coagulation function were observed 1 day after treatment. Results 46 cases were cured, 6 died, the cure rate was 88.5%. The platelet counts, the prothrombin time (PT) were significantly shorter in patients with transfusion of platelets, cryoprecipitate, prothrombin complex, plasma and heparin than those before transfusion in 52 patients. Fibrinogen (Fbg) content increased. Conclusion Early treatment of multiple traumatic patients with DIC complicated with platelet, cryoprecipitate, prothrombin complex, plasma and heparin can effectively prevent the continuous development of DIC, reconstruct the coagulation mechanism and restore the function of the body.