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The long- term evolution of Hu antibody (Hu- Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu- Ab titers in 35 patients with PNS with a median follow- up of 32 months (range 6 to 108 months). No correlation was observed between Hu- Ab titers and neurologic outcome, tumor evolution, or type of treatment. Serial Hu- Ab determinations are not useful for monitoring the clinical outcome of patients with PNS.
The long-term evolution of Hu antibody (Hu- Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu- Ab titers in 35 patients with PNS with a median follow- up of 32 months (range 6 to 108 months). No correlation was observed between Hu- Ab titers and neurologic outcome, tumor evolution, or type of treatment. Serial Hu- Ab determinations are not useful for monitoring the clinical outcome of patients with PNS.