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测定ＭＩＣ是估计抗真菌药物敏感性和决定治疗方案的有效方法。我们用微量稀释法测定了８０株念珠菌和２０株新型隐球菌对三唑类抗真菌药氟康唑的敏感性。结果发现白念珠菌４０株敏感（７６．９２％），７株耐药，５株中介。克柔念珠菌几乎全部耐药，光滑念珠菌及热带念珠菌多数非敏感。新型隐球菌ＭＩＣ均值高于念球菌属。来自阴道分泌物的白念珠菌其耐药频率高于其它来源的菌株。电泳核型Ⅱ型菌株氟康唑非敏感株显著多于Ⅰ型菌株。这些结果表明临床进行抗真菌治疗及监测时测定药物敏感性及菌种鉴定是十分重要的。
Determining MICs is an effective way to assess antifungal susceptibility and determine treatment regimens. We measured the sensitivity of 80 strains of Candida and 20 strains of Cryptococcus neoformans to the triazole antifungal fluconazole using the microdilution method. The results showed that 40 strains of Candida albicans were sensitive (76.92%), 7 were resistant and 5 were medium. Candida krusei almost all drug-resistant, Candida glabrata and Candida tropicalis most non-sensitive. The mean of Cryptococcus neoformans was higher than that of Candida. Candida albicans from vaginal discharge is more resistant than other strains. Electrophoresis karyotype type II fluconazole non-sensitive strains were significantly more than type Ⅰ strains. These results indicate that it is very important to determine the drug sensitivity and identification of bacteria in the clinical antifungal therapy and monitoring.