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在应用丙戊酸及大剂量维生素B_6 20mg～50mg/(kg·d)的基础上,加用小剂量人工合成的ACTH—长效确杜先0.01mg～0.015mg/(kg·d)治疗症状性婴儿痉挛症23例。长效确杜先疗程结束后1月,21例患儿(91.3％)的发作得到完全控制,长效确杜先用药至抽搐发作完全停止的平均时间为3.5天±1.6天(1.5天～5.0天)。23例患儿平均随访(15.2±12.1)月(3月～26个月),4例(17.4％)患儿出现复发,无演变为其它类型发作者。10例(43.5％)出现肝酶一过性增高,8例(34.8％)出现短暂的、不同程度的兴奋症状,无严重的毒副作用发生。
In the application of valproic acid and large doses of vitamin B_6 20mg ~ 50mg / (kg · d), based on the addition of small doses of synthetic ACTH-long-acting Du first 0.01mg ~ 0.015mg / (kg · d) treatment of symptoms Sexual infantile spasms in 23 cases. Long-acting Duoduan January after the end of treatment, 21 patients (91.3%) of the seizures were fully controlled, long-acting Du drug to convulsive seizures completely stopped the average time of 3.5 days ± 1.6 days (1.5 days to 5.0 day). The average follow-up of 23 children (15.2 ± 12.1 months) (March to 26 months) and the recurrence of 4 cases (17.4%) did not evolve into other types of children. Eleven patients (43.5%) had a transient elevation of liver enzymes, and 8 (34.8%) had transient and varying degrees of excitement without serious side effects.