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目的:观察四逆散合半夏厚朴汤加减辨治肝火犯肺型小儿咳嗽的临床效果。方法:将80例肝火犯肺型小儿咳嗽患者随机分为对照组和治疗组各40例。对照组予抗生素、化痰药物进行基础治疗,治疗组在常规用药基础上予四逆散合半夏厚朴汤加减治疗,连续治疗1周。观察患者的症状改善情况,评估主要证候积分,记录主要症状缓解、消失时间,计算临床疗效,检测治疗前后炎性因子水平的改善情况。结果:治疗组临床症状改善情况优于对照组,其证候积分下降更显著,患者的咳嗽、肺部啰音、X线胸片等改善、消失时间明显短于对照组患者;治疗组有效率为92.5%,显著高于对照组的72.5%;治疗组血清炎性因子hs-CRP、IL-6、TNF-α水平显著低于对照组,差异均有统计学意义(P<0.05)。结论:四逆散合半夏厚朴汤加减能显著改善肝火犯肺型咳嗽小儿的临床症状,有效缩短症状改善、消失时间,疗效确切,其机制与降低炎性因子水平有一定的相关性。
Objective: To observe the clinical effects of treating Sinihuang Sanpu Hupu Decoction with Siniosan and Banxiahuopu Decoction. Methods: 80 cases of liver fire foci of children with cough were randomly divided into control group and treatment group of 40 cases. Control group to antibiotics, phlegm drugs for basic treatment, the treatment group on the basis of conventional medication to Sini Powder Plus Banxia Houpu treatment, continuous treatment for 1 week. Observe the symptoms of patients to improve, assess the main syndrome points, record the main symptoms of remission, disappear time, calculate the clinical efficacy, test the level of inflammatory cytokines before and after treatment to improve the situation. Results: The improvement of clinical symptoms in the treatment group was better than that in the control group, and its syndrome score decreased more significantly. The improvement and disappearance time of the cough, pulmonary rales and X-ray in the treatment group were significantly shorter than those in the control group. The treatment group (92.5%) was significantly higher than that of the control group (72.5%). The levels of serum inflammatory cytokines hs-CRP, IL-6 and TNF-α in the treatment group were significantly lower than those in the control group (P <0.05). CONCLUSION: The addition and subtraction of Banxia Powder and Banxia Houpu Decoction can significantly improve the clinical symptoms of infantile cough in children with liver fire and effectively shorten the symptoms and disappear time. The curative effect is definite. The mechanism is related to the reduction of inflammatory factors.