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目的观察银杏叶制剂对哮喘儿童气道炎症和辅助T细胞(Th)亚群的影响。方法68例中、重度哮喘儿童随机分为两组:激素治疗组32例,单纯吸入布地奈德气雾剂治疗6个月;联合治疗组36例,吸入布地奈德气雾剂且同时口服银杏叶片6个月。对治疗前后诱导痰液作嗜酸性细胞计数,并测定痰液中γ干扰素(IFN-γ)、白细胞介素(IL)5水平。同时以20例健康儿童为正常对照组。结果两哮喘组治疗前痰液中嗜酸性粒细胞、IL-5均显著高于正常对照组(P<0.01)。治疗后两组嗜酸性粒细胞、IL-5均下降(P<0.01),且联合治疗组低于激素治疗组(P<0.01)。各组间IFN-γ水平无统计学差异(P>0.05)。结论银杏叶片与布地奈德具有协同抗炎作用;银杏叶片可在一定程度上控制哮喘气道炎症和纠正失衡的Th亚群。
Objective To observe the effect of Ginkgo biloba extract on airway inflammation and helper T cell subsets in asthmatic children. Methods 68 cases of severe asthma children were randomly divided into two groups: hormone therapy group 32 cases, simple inhalation of budesonide aerosol treatment for 6 months; combination therapy group 36 cases, inhalation of budesonide aerosol and at the same time oral ginkgo Leaves for 6 months. The sputum eosinophil count was measured before and after treatment, and the levels of interferon-γ (IFN-γ) and interleukin (IL) 5 in sputum were measured. At the same time to 20 healthy children as the normal control group. Results The levels of eosinophils and IL-5 in sputum before asthma treatment were significantly higher than those in normal control group (P <0.01). Eosinophils and IL-5 in both groups decreased after treatment (P <0.01), and the combination therapy group was lower than the hormone therapy group (P <0.01). There was no significant difference in the levels of IFN-γ among the three groups (P> 0.05). Conclusion Ginkgo biloba has a synergistic anti-inflammatory effect with budesonide. Ginkgo biloba can control airway inflammation and correct unbalanced Th subpopulation to a certain extent.