无防腐剂滴眼液包装瓶的问题与改进

• 作 者: 孙旭光 张晓玉
• 机 构: 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室,
• 出 处: 眼科
• 发表日期: 2015年06期
• 关键词: eye drops preservatives-free packaging bottle

随着对滴眼液中防腐剂毒性作用的关注,无防腐剂滴眼液应运而生。目前,滴眼液中不加防腐剂,主要是通过包装瓶的改进而达到的,从单剂量包装瓶到多剂量包装瓶,各有其优劣。单剂量包装瓶携带方便,开启后暴露时间短,可基本避免微生物污染,但生产成本高,易导致滴眼液浪费增加。多剂量包装瓶,既做到了无防腐剂,又能多次使用,但需要患者改变使用习惯,对滴眼液的黏滞度也有一定要求,且眼药瓶本身的生产成本比例增大。随着对滴眼剂包装瓶研究设计的深入,滴眼液包装瓶应旨在安全简便、成本“亲民”、剂量可控。

With the concern about the antiseptic toxicity in eye drops, no preservative eye drops came into being. At present, there is no preservative in the eye drops, mainly achieved through the improvement of the packaging bottles, ranging from single-dose bottles to multi-dose bottles, each having advantages and disadvantages. Single-dose bottles easy to carry, open a short exposure time, can basically avoid microbial contamination, but the high cost of production, easily lead to increased waste of eye drops. Multi-dose bottles, both done without preservatives, but also can be used many times, but need to change the patient’s habits, the viscosity of the eye drops have certain requirements, and the proportion of the production cost of eye drops bottle itself increases. With the deepening of research and design of eye drops packaging bottles, eye drops bottles should be designed to be safe and easy, the cost of “people first”, dosage controllable.