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目的探讨血浆同型半胱氨酸(Hcy)、内皮素1(ET-1)和一氧化氮(NO)水平与高血压及其合并脑出血的关系。方法检测62例单纯高血压患者(A组)、45例单纯脑出血患者(B组)、60例高血压性脑出血患者(C组)和40名健康体检者(D组)血浆Hcy、ET-1和NO的水平。结果 A、B、C和D组的血浆Hcy分别为(17.6±6.6)μmol/L、(18.2±7.2)μmol/L、(21.9±6.7)μmol/L和(10.8±4.6)μmol/L;ET-1分别为(100.7±11.8)μg/L、(101.2±12.1)μg/L、(120.8±15.9)μg/L和(44.7±10.6)μg/L;NO分别为(57.2±11.7)mg/L、(58.6±11.2)mg/L、(41.8±13.2)mg/L和(120.8±12.6)mg/L。与D组比较,A、B和C组Hcy和ET-1水平升高,NO水平降低(P<0.05);C组Hcy和ET-1水平高于A、B组,NO水平低于A、B组(P<0.05)。脑出血量与血浆Hcy和ET-1水平呈正相关,而与NO水平呈负相关(P<0.05)。结论高血压性脑出血患者存在内皮细胞损害和内皮功能障碍。
Objective To investigate the relationship between plasma homocysteine (Hcy), endothelin-1 (ET-1) and nitric oxide (NO) and hypertension and its associated intracerebral hemorrhage. Methods Sixty-two patients with hypertension (group A), 45 patients with simple cerebral hemorrhage (group B), 60 patients with hypertensive intracerebral hemorrhage (group C) and 40 healthy subjects (group D) -1 and NO levels. Results Plasma Hey levels in groups A, B, C and D were (17.6 ± 6.6) μmol / L, (18.2 ± 7.2) μmol / L, (21.9 ± 6.7) μmol / L and (10.8 ± 4.6) μmol / (100.7 ± 11.8) μg / L, (101.2 ± 12.1) μg / L, (120.8 ± 15.9) μg / L and (44.7 ± 10.6) μg / L respectively for ET-1 and 57.2 ± 11.7 mg /L,(58.6 ± 11.2) mg / L, (41.8 ± 13.2) mg / L, and (120.8 ± 12.6) mg / L. The levels of Hcy and ET-1 in A, B and C groups were significantly higher than those in A, B and C groups (P <0.05), while the levels of Hcy and ET-1 in C group were higher than those in A and B groups Group B (P <0.05). The amount of cerebral hemorrhage was positively correlated with plasma Hcy and ET-1 levels, but negatively correlated with NO levels (P <0.05). Conclusion There are endothelial cell damage and endothelial dysfunction in patients with hypertensive intracerebral hemorrhage.