论文部分内容阅读
双相胰岛素释放,最初是20余年前在体外和人体上观察到的。第一时相是对快速、持续刺激的反应,以速率—敏感的短暂胰岛素释放为特征。第二时相是在第一时相之后1～2小时,胰岛素释放进行性增多持续1～2小时。随着时间的推移,研究者们对于正常人和糖尿病人双相分泌的意义,认识逐渐加深,认为第一时相与葡萄糖浓度变化速率成正比,对调节肝脏葡萄糖排出颇为重要,而
Biphasic insulin release was first observed in vitro and in humans more than 20 years ago. The first phase is a fast, sustained stimulus response characterized by rate-sensitive transient insulin release. The second phase is 1 to 2 hours after the first phase, and the progressive increase in insulin release lasts 1 to 2 hours. With the passage of time, researchers have deepened their understanding of the significance of biphasic secretion in normal people and diabetics. It is considered that the first phase is directly proportional to the rate of change of glucose concentration and is quite important for the regulation of hepatic glucose excretion.