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多囊性卵巢综合征,其病理本质是卵巢性雄激素产生过多。但是在卵巢内详细的产生部位不清楚。为了明确多囊性卵巢中雄激素产生过多的部位,分别研究了在体外多囊性卵巢的闭锁卵泡和间质组织类固醇激素的合成功能。以5例多囊性卵巢患者为对象,从其楔形切除时得到的卵巢片,分离摘出最大直径的卵泡和间质。用含1-~(14)C-醋酸钠的Hanks液中孵育3小时,对孕激素类、雄激素类和雌激素类等8种性类固醇,采用逆向同位素稀释法(reverse isotope dilution technique)和再结晶法进行分析。从3例典型的多囊性卵巢中得到的卵泡,发现
Polycystic ovary syndrome, the pathological nature of ovarian androgen excess. However, the detailed production site in the ovary is unclear. In order to clarify the site of excessive androgen production in polycystic ovary, the synthesis of atherogenic follicles and interstitial steroid hormones in polycystic ovary in vitro were studied. Five patients with polycystic ovary were selected as the ovaries from ovariectomized rats, and the follicles with the largest diameter and the interstitium were isolated. After incubation for 3 hours in Hanks solution containing 1- (14) C-sodium acetate, the reverse isotope dilution technique was used for the determination of eight sex steroids such as progestins, androgens and estrogens and Recrystallization method for analysis. Follicles obtained from 3 cases of typical polycystic ovary were found