论文部分内容阅读
目的比较托吡酯、丙戊酸钠与托吡酯联合丙戊酸钠治疗小儿癫痫的临床效果及不良反应。方法选择2009年5月—2012年4月收治的160例癫痫患儿,随机分为托吡酯组(A组)58例,丙戊酸钠组(B组)54例,托吡酯与丙戊酸钠联合治疗组(C组)48例,A组给予托吡酯,初始剂量为1.50 mg.kg-1.d-1,每周增加0.50~1.00 mg.kg-1.d-1,目标剂量8 mg.kg-1.d-1。B组给予丙戊酸钠:起始剂量5~10 mg.kg-1.d-1,每周增加5 mg.kg-1.d-1,至20~30 mg.kg-1.d-1后维持治疗。C组同时给予托吡酯及丙戊酸钠:丙戊酸钠起始剂量5~10 mg.kg-1.d-1,每周增加5 mg.kg-1.d-1,至20~30 mg.kg-1.d-1后维持治疗。托吡酯起始剂量0.50~1.00 mg.kg-1.d-1,每周增加0.50~1.00 mg.kg-1.d-1,至目标剂量4~8 mg.kg-1.d-1。结果 A组、B组和C组总有效率分别为82.8%、75.9%和95.8%,C组与A组、B组比较差异均有统计学意义(均P<0.05)。结论托吡酯联合丙戊酸钠治疗小儿癫痫的临床疗效显著,优于单一药物治疗,值得临床推广应用。
Objective To compare the clinical effects and adverse reactions of topiramate, sodium valproate and topiramate combined with sodium valproate in the treatment of children with epilepsy. Methods A total of 160 children with epilepsy who were admitted to our hospital from May 2009 to April 2012 were randomly divided into topiramate group (A group) 58 cases, sodium valproate group (B group) 54 cases, topiramate combined with sodium valproate The treatment group (group C) 48 cases, group A was given topiramate, the initial dose of 1.50 mg.kg-1.d-1, weekly increase of 0.50 to 1.00 mg.kg-1.d-1, the target dose of 8 mg.kg -1.d-1. Group B was given sodium valproate: the initial dose of 5 ~ 10 mg.kg-1.d-1, weekly increase of 5 mg.kg-1.d-1, to 20 ~ 30 mg.kg-1.d- 1 after treatment. Group C also given topiramate and sodium valproate: sodium valproate starting dose of 5 ~ 10 mg.kg-1.d-1, weekly increase of 5 mg.kg-1.d-1, to 20 ~ 30 mg .kg-1.d-1 maintenance treatment. Topiramate starting dose of 0.50 ~ 1.00 mg.kg-1.d-1, weekly increase 0.50 ~ 1.00 mg.kg-1.d-1, to the target dose of 4 ~ 8 mg.kg-1.d-1. Results The total effective rates of group A, group B and group C were 82.8%, 75.9% and 95.8% respectively. There was significant difference between group C and group A and B (all P <0.05). Conclusion Topiramate combined with sodium valproate in children with epilepsy clinical efficacy was significantly better than single drug treatment, it is worthy of clinical application.