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目的：研究氢醌对小鼠和大鼠的急性毒性和蓄积毒性，为建立卫生标准提供资料。方法：选用昆明种小鼠６０只，Ｓ．Ｄ雌性大鼠３０只，以氢醌（ＨＱ）乳化液，分别按０～９００ｍｇ／ｋｇ和０～２１５０ｍｇ／ｋｇ各分５个剂量组，一次性灌胃染毒。选用昆明种小鼠５０只，Ｓ．Ｄ雌性大鼠２５只，以ＨＱ乙醇溶液，分别按０～３８４０ｍｇ／ｋｇ各分５个剂量组一次性皮肤涂布染毒；另选昆明种小鼠４０只，以剂量定期递增染毒法灌胃，起始染毒剂量为０．１ＬＤ５０，以后每４天递增剂量１．５倍，共２０天，后观察５天，再给予一个ＬＤ５０的ＨＱ水溶液。结果：ＨＱ的急性毒作用表现为抽搐、震颤、瘫痪、呼吸困难，最后死亡。小鼠经口ＬＤ５０为３９９．８ｍｇ／ｋｇ，大鼠经口ＬＤ５０为５８４ｍｇ／ｋｇ。小鼠经皮染毒最小致死量大于４８００ｍｇ／ｋｇ，大鼠为大于３８４０ｍｇ／ｋｇ。结论：ＨＱ急性毒性属中等毒类，于小鼠体内有轻度蓄积作用。
Objective: To study the acute toxicity and accumulative toxicity of hydroquinone to mice and rats, and to provide information for establishing health standards. Methods: 60 Kunming mice were used, S. D female rats, respectively. Hydroquinone (HQ) emulsion, respectively, by 0 ~ 900mg / kg and 0 ~ 2150mg / kg each of the five dose groups, a single intragastric administration. Selected Kunming mice 50, S. D female rats 25, with HQ ethanol solution, respectively, according to 0 ~ 3840mg / kg sub-5 groups of single-dose skin coating exposure; alternatively Kunming mice 40, the dose of regular irrigation The stomach, the initial dose of 0.1LD50, every 4 days after the dose escalating 1.5 times for a total of 20 days after the observation of 5 days, and then given an LD50 HQ aqueous solution. RESULTS: The acute toxic effects of HQ were convulsions, tremor, paralysis, dyspnea, and finally death. The oral LD50 of mice was 399.8 mg / kg, and the oral LD50 of rats was 584 mg / kg. Mouse transdermal exposure to a minimum lethal dose greater than 4800mg / kg, rats greater than 3840mg / kg. Conclusion: HQ acute toxicity is a moderate toxic, mild accumulation in mice.