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目的:检测慢性乙型肝炎患者血清中相关细胞因子的水平,为慢性乙型肝炎肝纤维化的分期提供诊断依据。方法:选择175例在我院接受治疗的慢性乙型肝炎患者作为研究对象,采用ELISA方法检测患者血清中基质金属蛋白酶抑制剂(TIMP-1,TIMP-2)、脂连素及其受体(AdipoQ)、瘦素(Leptin)、生长因子(PDGF)、骨桥蛋白(OPN)6项指标的含量,并利用ROC曲线对各指标与肝纤维化分期之间的关系进行相关性分析。结果:TIMP-1、TIMP-2、Leptin在不同纤维化组中呈差异性表达,且AUROC高于其他指标(P<0.05);其余指标无统计学意义(P>0.05)。结论:TIMP-1、TIMP-2、Leptin这3项指标对慢性乙型肝炎肝纤维化分期具有一定的辅助诊断价值,与其他指标相结合可获得更好的诊断效能。
Objective: To detect serum levels of related cytokines in patients with chronic hepatitis B, and to provide a diagnosis basis for the staging of chronic hepatitis B liver fibrosis. Methods: A total of 175 patients with chronic hepatitis B treated in our hospital were enrolled in this study. Serum levels of TIMP-1, TIMP-2, adiponectin and their receptors AdipoQ, Leptin, growth factor (PDGF) and osteopontin (OPN) were detected by ELISA. The correlation between each index and the stage of liver fibrosis was analyzed by ROC curve. Results: TIMP-1, TIMP-2 and Leptin were differentially expressed in different fibrosis groups, and AUROC was higher than other indexes (P <0.05). There was no significant difference between the other indexes (P> 0.05). CONCLUSION: The three indexes of TIMP-1, TIMP-2 and Leptin have some auxiliary diagnostic value for the staging of liver fibrosis in patients with chronic hepatitis B. Combined with other indexes, better diagnostic efficacy can be obtained.