Effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-t

• 作 者: Li-Ran Fu Sheng-Wei Guo Xian-Hui Liu
• 机 构: Department of Internal ,TCM Medicine,People' Hospital Affiliated to Southern Medical University,Tumo
• 出 处: Asian Pacific Journal of Tropical Medicine
• 发表日期: 2014年05期
• 关键词: colorectal anticancer spleen decoction nude inhibit colon hematoxylin alone Zhen

Objective:To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cell HT29 xenograft of nude mice model was established.The expression of ECF,VEGF,gastric cancer tumor growth in mice were observed.Results:Protein kinase C expression in in the Yiqi Jianpi group and Yiqi Jianpi anti-tumor group was significantly better than the model group(P<0.01,P<0.05).There was significantly more apoptotic cells in Yiqi Jianpi anti-tumor group than Yiqi Jianpi group and model group(P<0.01).Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group(P<0.05).Conclusions:Tumor can inhibit the expression of PKC inhibition.Yiqi Jianpi and anticancer treatment can reduce this inhibition.Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.

Objective: To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role. Methods: Human intestinal cancer cell HT29 xenograft of nude mice model was established. The expression of ECF, VEGF, gastric cancer tumor growth in mice were observed. Results: Protein kinase C expression in the Yiqi Jianpi group and Yiqi Jianpi anti-tumor group was significantly better than the model group (P <0.01, P <0.05) .here was significantly more apoptotic cells in Yiqi Jianpi anti-tumor group than Yiqi Jianpi group and model group (P <0.01) .Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group (P <0.05) .Conclusions: Tumor can inhibit the expression of PKC inhibition. Yiqi Jianpi and anticancer treatment can reduce this inhibition. Beside this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothe lial growth factor.