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利血平(1.5mg/kg,ip)单独给药后24h能显著降低大鼠脑内NA(—60%)和DA(—75%)。预先给予dl-THP(60mg/kg)能使脑内NA和DA进一步下降,分别为正常对照组的15和5%,与单给利血平组有显著性差别。dl-THP同样亦能协同利血平排空5HT的作用。相反,预先给予丁苯那嗪(50mg/kg)则部分拮抗利血平的排空作用。此外,dl-THP与利血平不同,对Na~+K~+-ATP酶和Mg~(2+)-ATP酶活性无显著影响。l-或d-THP在10~(-4)mol/L的较高浓度下能诱发豚鼠输精管节律性收缩,并不被多种受体阻断剂拮抗。在体研究表明,dl-THP在较大剂量下与利血平相似,降低犬鼠体温。
Reserpine (1.5mg / kg, ip) 24h after administration can significantly reduce NA (-60%) and DA (-75%) in rat brain. Pretreatment with dl-THP (60 mg / kg) led to a further decrease of NA and DA in the brain, which were 15 and 5% of those in the normal control group, respectively, which were significantly different from those in the single-dose reserpine group. dl-THP can also synergize reserpine 5HT role. In contrast, pre-administration of tetrabenazine (50 mg / kg) partially antagonized the emptying effect of reserpine. In addition, dl-THP, unlike reserpine, had no significant effect on Na ~ + K ~ + -ATPase and Mg ~ (2 +) - ATPase activity. l- or d-THP induced rhythmic vasoconstriction in guinea pigs at higher concentrations of 10 -4 mol / L and were not antagonized by various receptor blockers. In vivo studies showed that, dl-THP at higher doses and reserpine similar to reduce body temperature in canine.