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采用小空间细颗粒饲养方法研究长时间近距离注视对青少年恒河猴屈光状态发育和玻璃体腔长度变化的影响.将12只1.5~2.0岁健康恒河猴随机分为三组,每组四只.其中A组和B组每天分别置于视觉封闭的猴笼内饲养8和4h,同时将食物处理成细小颗粒状置于代谢盘中(需仔细翻找才能获得).每3个月进行一次眼轴长度、玻璃体腔长度、屈光状态和角膜曲率测量,总观察周期为18个月.采用对照t检验进行数据分析,P<0.05有显著性意义.结果显示,观察期间A组眼轴和玻璃体腔长度增长最为显著,屈光状态明显向近视化方向发展;B组眼轴和玻璃体腔长度也有明显增长,但屈光度无明显变化;C组眼轴和玻璃体腔长度增长最为缓慢,屈光度轻度向远视化方向发展.观察期间各组的角膜曲率均无明显改变.研究结果表明,强制性近距离注视能够加快青少年恒河猴玻璃体腔长度的增长,导致单纯性近视的发生与发展,是建立近距离工作相关的灵长类近视眼动物模型的可行性方法.
The effect of long-term close gaze on the development of refractive status and the length of vitreous cavity in juvenile rhesus monkeys was investigated by small-particle fine-grazing method.All 12 healthy rhesus macaques aged 1.5 ~ 2.0 years were randomly divided into three groups of four Only group A and group B were housed in the visually-enclosed monkey cages for 8 and 4 h, respectively, while the food was processed into fine granules placed in the metabolic disk (to be carefully scrutinized to obtain.) Every 3 months The axial length, vitreous cavity length, refractive state and corneal curvature measurement, the total observation period of 18 months.With the control t test data analysis, P <0.05 was significant.Results showed that during the observation group A axial And the length of the vitreous cavity increased most significantly, the refractive status evolved to the direction of myopia. The length of the ocular axis and the vitreous cavity in group B also increased obviously, but there was no significant change in the refractive power. The length of the ocular and vitreous cavity in group C was the slowest increase, Degrees to the direction of hyperopia development during the observation period corneal curvature of each group had no significant change.The results show that forced close gaze can speed up the growth of adolescent rhesus vitreous cavity length, resulting in simple The occurrence and development of myopia, is the establishment of close work-related feasibility primate animal model of myopia.