血清放射免疫胰岛素和真胰岛素测定对胰岛β细胞功能评价(英文)

• 作 者: 马博清 宋光耀 叶蔚 薛树正 张文杰 王智华
• 机 构: 河北省人民医院老年医学研究所,河北省人民医院老年医学研究所,河北省人民医院老年医学研究所,河北省人民医院老年医学研究所,河北省人民医院老年医学研究所,河北省人民医院老年医学研究所 石家庄 050051
• 出 处: 中国医学工程
• 发表日期: 2002年06期
• 关键词: 胰岛β细胞功能 obese impaired subgroups monoclonal subdivided evaluating Insulin 归一 nor

Objective:To study the changes of true insulin(TI) and immunoreactive insulin (IRI) in subjectswith NGT, IGT and DM, to study the difference betwee true insulin and immunoreactive insulin in evaluating β-cell function and insulin sensitivity. Methods: The levels of serum IRI and TI were determined in 54 cases with typeⅡ diabetes mellitus(Group DM),43 cases with impaired glucose tolerance (Group IGT) and 75 cases with normalglucose tolerance (Group NGT). Then every group was subdivided into obese and non-obese subgroups according tobody mass index. IRI was determined by RIA. TI was determined by ELISA using monoclonal antibody with no sig-nificant cross-reaction between insulin and proinsulin. The insulin resistance index (Homa-IR), pancreatic β-cell

Objective: To study the changes of true insulin (TI) and immunoreactive insulin (IRI) in subjects with NGT, IGT and DM, to study the difference betwee true insulin and immunoreactive insulin in evaluating β-cell function and insulin sensitivity. Methods: The levels of serum IRI and TI were determined in 54 cases with type II diabetes mellitus (Group DM), 43 cases with impaired glucose tolerance (Group IGT) and 75 cases with normal glucose tolerance (Group NGT). Then every group was subdivided into obese and non- The IRI was determined by RIA. TI was determined by ELISA using monoclonal antibody with no sig-nificant cross-reaction between insulin and proinsulin. The insulin resistance index (Homa-IR), pancreatic β-cell