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黄连中含有6种原小檗碱型生物碱和木兰花碱。这些化合物的结构很近似。前人曾用数种溶剂系统均未能在TLC 有效地分离。作者等选用混合溶剂系统:①苯-乙酸乙酯-正丙醇-甲醇-乙胺(8:4:2:1:1);和②甲醇-水-氨(8:1:1)作展开剂,对21种黄连的生药样品的冷甲醇提取物进行硅胶TLC,然后于UV 线下观察,得出如下结果:(1)混合溶剂系统①能有效地分离原小檗碱型生物碱,尤其是对不具有酚羟基的生物碱分离效果更好。用①作溶剂系统展开后,从薄层板的顶端至
Coptis contains 6 kinds of original berberine alkaloids and magnoliaine. The structure of these compounds is very similar. Several previous solvent systems failed to effectively separate at TLC. The authors chose a mixed solvent system: ① benzene - ethyl acetate - n - propanol - methanol - ethylamine (8: 4: 2: 1: 1); and ② methanol - water - ammonia Agent, cold crude methanol extract of crude drug of 21 kinds of Coptis was TLC on silica gel and observed under UV light, the following results were obtained: (1) The mixed solvent system ① can effectively separate the original berberine alkaloids, especially Is better for the separation of alkaloids without phenolic hydroxyl. Use ① as a solvent system to expand, from the top of the plate to