论文部分内容阅读
目的研究中药胆胰和胃冲剂对胆道内环境成石因素的影响，并观察其预防术后胆石形成的临床效果．方法Ⅰ组应用自制中药胆胰和胃冲剂（由柴胡、金钱草、大黄，黄芩等１１味中药组成），选择胆道手术后胆道置管引流患者３６例，服该冲剂者２２例为服药组，不服药１４例为对照组．动态观察服药前后引流胆汁组分的变化，另设１５例服药，１０例对照，观察胆汁中氧自由基的变化，从多因素研究该冲剂对胆道内环境成石胆汁的影响．Ⅱ组肝胆管结石手术后取净结石患者２２４例，分２组，服药组１３０例，不服药对照组１１４例，随访１ａ～８ａ，观察胆石复发情况．结果Ⅰ组：服药组２２例，胆汁中胆酸显著增高（ｍｇ／Ｌ，７７９±５３６→９５７±７８８），胆红素，粘蛋白显著降低（分别由μｍｏｌ／Ｌ，５５５±２７２→３７６±２０６；ｍｇ／Ｌ，１６０±５８→１４２±４１，Ｐ＜００１）．对照组无变化．服药组胆汁组分胆酸∶胆固醇（服药前７７９±５３６∶８７７±５８８，后９５７±７９０∶８５０±４５７）；胆酸∶胆红素的比值（服药前７７９±５３６∶５５５±２７２，后９５７±７９０∶３７２±２０６），均呈动态升高（Ｐ＜００１）．Ⅲ组１５例，对照分组１０例，检查胆汁中Ｏ－２与ＳＯＤ?
Objective To study the effect of Chinese herb gallbladder and stomach granule on biliary factors in the biliary tract and to observe its clinical effect in preventing postoperative gallstone formation. Methods Ⅰ group with self-made Chinese medicine gallbladder and stomach granules (Bupleurum, Lysimachiae, rhubarb, skullcap and other 11 herbs), choledochosinus tube drainage in 36 patients after biliary tract administration, taking the granules in 22 patients for the medication group , 14 cases without medication for the control group. The changes of bile components in the drainage bile before and after treatment were observed dynamically. Another 15 patients took medicine and 10 controls. The changes of oxygen free radicals in bile were observed. Two hundred and seventy-two patients with nephrolithiasis were randomly divided into two groups. 130 patients in medication group and 114 patients in medication-free control group were followed up for 1a ~ 8a for observing the recurrence of gallstone. Results In group Ⅰ, 22 cases in the medication group had significantly increased bile acid (mg / L, 779 ± 536 → 957 ± 788) and bilirubin and mucin (respectively, μmol / L, 555 ± 272 → 376 ± 206; mg / L, 160 ± 58 → 142 ± 41, P <001). No change in the control group. The bile component of the medication group, bile acid: cholesterol (before taking medicine 779 ± 536: 877 ± 588, after 957 ± 790:850 ± 457); bile acid: bilirubin ratio (before taking medicine 779 ± 536:555 ± 272, after 957 ± 790:372 ± 206), all showed a dynamic increase (P <001). Ⅲ group 15 cases, control group 10 cases, check bile O-2 and SOD?