论文部分内容阅读
目的:了解我院药品不良反应(ADR)的发生情况。方法:对我院2003～2009年收集到的654例ADR报告进行分类统计和分析。结果:654例ADR中,男性与女性比例为1∶1.67,多发生于41～50岁的人群(占20.34%)。以静脉滴注和口服给药为主,分别为452例(占69.11%)、177例(占27.06%)。抗菌药物发生例数最多,有342例(占52.29%),其中,头孢菌素类、喹诺酮类和大环内酯类药分别为127例(占37.13%)、91例(占26.61%)、54例(占15.79%);其次为心脑血管系统药,有92例(14.07%)。ADR累及器官或系统以皮肤及其附件和消化系统损害为主,分别占25.54%、22.48%。结论:临床应加强ADR监测,合理使用抗菌药物,密切关注中药注射剂的使用。
Objective: To understand the incidence of adverse drug reaction (ADR) in our hospital. Methods: 654 ADR cases collected in our hospital from 2003 to 2009 were classified and analyzed. Results: Among 654 ADRs, the ratio of males to females was 1: 1.67, which mostly occurred in 41- to 50-year-olds (20.34%). The main intravenous drip and oral administration, respectively, 452 cases (69.11%), 177 cases (27.06%). There were 342 cases (accounting for 52.29%) of the total number of antibacterials, of which 127 cases (37.13%) and 91 cases (26.61%) were cephalosporins, quinolones and macrolides, 54 cases (15.79%); followed by cardiovascular and cerebrovascular drugs, 92 cases (14.07%). ADR involving organs or systems with skin and its accessories and digestive system damage, accounting for 25.54%, respectively, 22.48%. Conclusion: Clinical monitoring of ADR should be strengthened, antibacterial drugs should be used reasonably and pay close attention to the use of traditional Chinese medicine injections.