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目的：观察了银杏叶提取物Ｇ９３１２（主含银杏内酯）对ＣＣｌ４肝损伤模型的影响。方法：小鼠ｉｐ０．１５％ＣＣｌ４的橄榄油溶液，诱发肝损伤，观察肝脏的组织学改变，测定血清丙氨酸氨基转换酶（ＡＬＴ）、肝组织过氧化脂质（ＬＰＯ）和超氧化物歧化酶（ＳＯＤ）水平。结果：Ｇ９３１２对ＣＣｌ４肝损伤引起血清ＡＬＴ病理性升高有明显降低作用（Ｐ＜０．０１），并具有改善肝组织病理损害程度（Ｐ＜０．０５），抑制肝组织ＬＰＯ的升高和提高ＳＯＤ活性等药理作用（Ｐ＜０．０１）。结论：Ｇ９３１２具有保肝、降酶作用，药效机理似与其抗自由基肝损伤有关。
OBJECTIVE: To observe the effect of ginkgo biloba extract G 931 2 (mainly containing ginkgolide) on CCl 4 liver injury model. METHODS: Mouse ip 0.15% CCl4 in olive oil induced hepatic injury, histological changes in liver were observed, serum alanine aminotransferase (ALT), liver lipid peroxide (LPO) and superoxide were measured. Dismutase (SOD) levels. RESULTS: G 9312 significantly decreased the serum ALT pathological elevation caused by CCl4 liver injury (P<0.01), and had ameliorated the degree of liver pathological damage (P<0.05), inhibited the increase of LPO in liver tissue. High and increased pharmacological effects such as SOD activity (P<0.01). Conclusion: G 9312 has hepatoprotective and anti-enzymatic effects. The mechanism of drug efficacy seems to be related to its anti-free radical liver injury.