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目的分析~(125)I粒子植入联合多西他赛和顺铂(DP)方案对治疗中晚期肺鳞癌的临床疗效。方法选取84例中晚期肺鳞癌患者为研究对象,随机将患者分为实验组和对照组,每组各42例,实验组患者给予~(125)I粒子植入联合多西他赛和顺铂(DP)方案治疗,对照组患者给予DP方案化疗,分析比较两组患者的临床疗效及临床不良反应。结果实验组患者的临床治疗有效率为73.81%,明显较高对照组的47.62%(P<0.05);实验组患者的1年生存率(85.71%)及中位无进展生存期[(6.3±1.4)个月]明显高于对照组[54.76%,(3.8±1.1)个月](P<0.05);两组患者临床不良反应主要为白细胞及血小板数目减少、恶心呕吐等症状,但程度均较轻(P>0.05)。结论~(125)I粒子植入联合多西他赛和顺铂(DP)方案治疗中晚期肺鳞癌的临床疗效肯定,患者生存期可得到延长,毒副作用较小,该化疗方案可为临床治疗中晚期肺鳞癌提供参考价值。
Objective To analyze the clinical efficacy of ~(125)I seed implantation combined with docetaxel and cisplatin (DP) for the treatment of advanced lung squamous cell carcinoma. Methods Eighty-four patients with advanced lung squamous cell carcinoma were selected as study subjects. The patients were randomly divided into experimental group and control group, with 42 cases in each group. Patients in the experimental group were given ~(125)I seed implantation with docetaxel and cisplatin. The platinum (DP) regimen was used to treat the patients in the control group and the DP regimen was given chemotherapy. Clinical efficacy and clinical adverse reactions were analyzed and compared between the two groups. Results The effective rate of clinical treatment in the experimental group was 73.81%, which was significantly higher in the control group (47.62%) (P<0.05). The 1-year survival rate (85.71%) and median progression-free survival rate in the experimental group [(6.3±) 1.4) months] was significantly higher than the control group [54.76%, (3.8 ± 1.1) months] (P <0.05); the clinical adverse reactions in the two groups were mainly the reduction of white blood cell and platelet count, nausea and vomiting, but the degree was Lighter (P>0.05). Conclusion The clinical efficacy of ~(125)I seed implantation combined with docetaxel and cisplatin (DP) regimens for the treatment of advanced lung squamous cell carcinoma is affirmative. The survival period of patients can be prolonged with fewer side effects. The chemotherapy regimen can be clinical Treatment of advanced lung squamous cell carcinoma provide reference value.