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目的研究S100A7蛋白对局部复发性鼻咽癌(NC)患者挽救术治疗前放疗效应的预测价值。方法选择局部复发性NC患者35例作为研究对象。另选同期于医院接受治疗的慢性鼻咽炎患者40例作为对照。对比S100A7在不同病变组织中的表达,局部复发性NC患者不同放疗效应的S100A7表达,分析S100A7蛋白表达预测局部复发性NC放疗效应的敏感性、特异度、准确度。结果局部复发性NC的S100A7表达阳性率为85.71%(30/35),显著高于慢性鼻咽炎的5.00%(2/40),差异有统计学意义(P<0.05)。不同病理分期和临床分型中低档S100A7的表达差异无统计学意义(P>0.05)。放射抵抗的局部复发性局部复发性NC S100A7阳性表达率和阴性表达率显著高于放射敏感,差异有统计学意义(P<0.05)。S100A7蛋白的阳性表达对局部复发性NC在挽救术治疗前放疗效应的预测价值中,敏感性、特异度及准确度均大于50%。结论 S100A7蛋白对于局部复发性NC患者接受挽救术治疗前的放疗效应具有较好的预测价值,值得重视。
Objective To study the predictive value of S100A7 protein in radiotherapy before salvage operation in patients with locally recurrent nasopharyngeal carcinoma (NC). Methods 35 patients with locally recurrent NC were selected as the study subjects. In the same period, 40 patients with chronic nasopharyngitis treated in the hospital were selected as control. To compare the expression of S100A7 in different pathological tissues and the expression of S100A7 under different radiotherapy effects in patients with locally recurrent NC. The sensitivity, specificity and accuracy of S100A7 protein expression in predicting the local recurrence of NC radiotherapy were analyzed. Results The positive rate of S100A7 expression in locally recurrent NC was 85.71% (30/35), which was significantly higher than that in chronic nasopharyngitis (5.00%, 2/40). The difference was statistically significant (P <0.05). There was no significant difference in the expression of S100A7 between middle and low grade in different pathological stages and clinical classification (P> 0.05). Radiation-resistant local recurrence of local recurrence NC S100A7 positive expression rate and negative expression was significantly higher than radiation-sensitive, the difference was statistically significant (P <0.05). The positive expression of S100A7 protein in predicting the predictive value of radiotherapy for locally recurrent NC before salvage therapy is more than 50%. Conclusion The S100A7 protein has good predictive value for radiotherapy before salvage in patients with locally recurrent NC.