,Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities

来源 :Acta Pharmaceutica Sinica B | 被引量 : 0次 | 上传用户:lrqnm
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Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L. Two new compounds, named lycium lignan D (1) and lyciumphenyl propanoid A (2) along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR- ESI- MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3-9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol / L.
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