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目的探讨血清脂联素、高敏C反应蛋白(hs-CRP)在动脉粥样硬化发生发展过程中的作用及病理生理意义。方法选取冠心病组患者123例(单支病变38例,双支病变43例,三支病变42例)和正常对照组48例,检测血清脂联素、hs-CRP水平并进行组间比较。结果血清脂联素水平冠心病各组均明显低于对照组(P均<0.05);双支、三支病变组显著低于单支病变组(P均<0.05);三支病变组稍低于双支病变组,但差异无统计学意义(P>0.05)。hs-CRP水平在单支、双支、三支病变组随冠脉病变支数的增加而递增,两两比较差异均有统计学意义(P均<0.05);且双支、三支病变组亦明显高于对照组(P均<0.05),单支病变组与对照组比较则差异无统计学意义(P>0.05)。结论脂联素和hs-CRP与冠脉病变程度及范围密切相关,对冠心病的病变程度及预后具有一定的预测价值。
Objective To investigate the role of serum adiponectin and high-sensitivity C-reactive protein (hs-CRP) in the development of atherosclerosis and its pathophysiological significance. Methods 123 cases of coronary heart disease (38 cases of single lesions, 43 cases of double-vessel lesions, 42 lesions of three lesions) and 48 cases of normal control group were selected. Serum levels of adiponectin and hs-CRP were measured and compared between groups. Results The levels of serum adiponectin in all groups were significantly lower than those in control group (all P <0.05). The levels of serum adiponectin in patients with double-vessel and triple-vessel disease were significantly lower than those of single vessel disease group (all P <0.05) In the double-vessel disease group, the difference was not statistically significant (P> 0.05). The levels of hs-CRP in single, double and triple lesion groups increased with the increase of coronary lesion count (P <0.05), and the difference between two groups and three lesion group (P <0.05). There was no significant difference between the single-vessel lesion group and the control group (P> 0.05). Conclusion Adiponectin and hs-CRP are closely related to the degree and extent of coronary artery disease, and have certain predictive value on the degree and prognosis of coronary heart disease.