论文部分内容阅读
近15年来,人们对食物—药物的相互作用的认识,接受和研究有所增强,尽管许多研究人员已经探讨了食物的摄取对各种药物的药代动力学和药效学的影响,但由于影响因素太多,很难解释药物食物的相互作用的临床数据,且它们之间的相互关系使食物改变药物吸收的机制难以确定,也难以预测变化的大小,由食物引起药物的吸收较小的变化,特别是当药物的吸收方式在不同病人身上表现出相当大的差异时,不可能具有临床意义。
In the past 15 years, people’s understanding, acceptance and research on food-drug interactions have been strengthened. Although many researchers have explored the influence of food intake on the pharmacokinetics and pharmacodynamics of various drugs, Too many factors make it difficult to interpret clinical data on the interaction of drug foods and their interrelationships make it difficult to determine the mechanism by which food changes drug absorption and to predict the magnitude of change that results in less drug absorption by food Changes, especially when the drug’s absorption patterns show considerable differences in different patients, are unlikely to be clinically relevant.