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目的:探讨宫颈液基薄层细胞学(TCT)在宫颈早期病变发现中的应用价值。方法:对22～80岁2 614例患者的宫颈TCT结果结合宫颈活检组织学对照分析。结果:检出未明确诊断意义的非典型鳞状细胞(ASC-US)以及以上病变89例(3.40%),其中ASC-US 35例,非典型鳞状细胞-不除外上皮内高度病变(ASC-H)12例,低度鳞状上皮内病变(LSIL)24例,高度鳞状上皮内病变(HSIL)18例。80例进行宫颈活检组织病理学检查,其中30例ASC-US组织学证实阳性8例(26.67%),CIN1 5例(17%),CIN2 1例(3%),CIN3 2例(7%);9例ASC-H中CIN1 1例(11%),CIN2 1例(11%),CIN3 5例(55%)。LSIL、HSIL与组织病理学一致率分别是59.10%、94.11%。2例细胞学阴性,活检诊为鳞癌。结论:LSIL、HSIL的诊断与组织学的符合率较高,ASC-US则较低,其准确性的提高具有很重要的意义,以组织学为对照,有利于积累经验。
Objective: To investigate the value of cervical cytology-based cytology (TCT) in the detection of early cervical lesions. Methods: Cervical TCT results of 2 614 patients 22 to 80 years of age combined with cervical biopsy histological control analysis. Results: There were 89 cases (3.40%) of atypical squamous cells (ASC-US) with undetermined diagnosis, 35 cases of ASC-US and atypical squamous cells- -H) 12 cases, low grade squamous intraepithelial lesion (LSIL) 24 cases, high grade squamous intraepithelial lesion (HSIL) 18 cases. Cervical biopsy was performed in 80 cases, of which 30 cases were ASC-US histologically proved positive in 8 cases (26.67%), CIN1 in 5 cases (17%), CIN2 in 1 case (3%) and CIN3 in 2 cases 1 case (11%) of CIN1 in 9 cases of ASC-H, 1 case (11%) of CIN2 and 5 cases (55%) of CIN3. The consistent rates of LSIL, HSIL and histopathology were 59.10% and 94.11% respectively. 2 cases of cytology negative, biopsy diagnosis of squamous cell carcinoma. Conclusion: The coincidence rates of LSIL and HSIL in diagnosis and histology are high, ASC-US is lower, and the accuracy of LSIL and HSIL is very important. Using histology as control, it is good for accumulating experience.