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目的：探讨多梗塞痴呆和Ａｌｚｈｅｉｍｅｒ型痴呆患者神经心理功能与局部脑血流的关系。方法：对３３例多梗塞痴呆（ＭＩＤ）、２１例Ａｌｚｈｅｉｍｅｒ型痴呆（ＤＡＴ）病人和２４例健康对照组作了单光子发射计算机断层显像（ＳＰＥＣＴ）检查，采用相对定量法测定局部脑血流（ｒＣＢＦ）。并作神经心理学测验。结果：ＭＩＤ病人左额颞叶ｒＣＢＦ与言语智商（ＶＩＱ）相关显著；左额、右顶、丘脑ｒＣＢＦ与总智商（ＦＩＱ）明显相关；左颞、右顶叶ｒＣＢＦ与脑损伤指数（ＤＱ）相关明显。ＤＡＴ病人左颞、右额叶ｒＣＢＦ与ＶＩＱ，右顶枕叶ｒＣＢＦ与操作智商（ＰＩＱ），左额颞、右顶叶ｒＣＢＦ与ＤＱ相关明显。ＭＩＤ、ＤＡＴ病人左颞叶ｒＣＢＦ与记忆商数（ＭＱ）相关显著。结论：提示ＭＩＤ、ＤＡＴ病人智能减退与脑血流降低有关。
Objective: To investigate the relationship between neuropsychological function and regional cerebral blood flow in patients with multi-infarct dementia and Alzheimer’s dementia. Methods: Single photon emission computed tomography (SPECT) was performed on 33 patients with multi-infarct dementia (MID), 21 patients with Alzheimer’s dementia (DAT) and 24 healthy controls. The relative cerebral blood flow (RCBF). And for neuropsychological test. Results: rCBF in left frontal and temporal lobe was significantly correlated with speech IQ (VIQ); rCBF in left frontal, right top and thalamus were significantly correlated with total intelligence (FIQ); rCBF in left temporal and right parietal lobes was correlated with brain injury index (DQ) obvious. DAT patients with left temporal, right frontal lobe rCBF and VIQ, right occipital lobe rCBF and operational intelligence (PIQ), left frontal temporal, right parietal rCBF and DQ significant correlation. There was a significant correlation between rCBF and memory quotient (MQ) in the left temporal lobe of patients with MID and DAT. Conclusion: It is suggested that patients with MID and DAT have decreased intelligence and decreased cerebral blood flow.