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目的:分析阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并卵圆孔未闭（PFO）患者的睡眠质量和睡眠结构特点，并探讨PFO对OSAHS患者睡眠结构的影响。方法:收集2018年12月至2020年3月于郑州大学第二附属医院睡眠中心就诊的OSAHS合并PFO患者56例、单纯OSAHS患者64例和健康对照组62例，应用匹兹堡睡眠质量指数（PSQI）问卷和多导睡眠监测对3组的睡眠质量和睡眠结构进行分析比较。结果:与对照组［6/62（9.68%）］比，OSAHS合并PFO组［54/56（96.43%）］和单纯OSAHS组［53/64（82.81%）］睡眠质量差者比例更高（χ2=112.08， n P<0.01），睡眠效率降低［PSQI得分分别为0.5（0， 1）、2（1， 3）分和2（1， 2）分，n H=74.549， n P<0.01］，快速眼球运动睡眠期（分别为20.45%±3.49%、12.19%±5.95%和15.11%±7.21%，n F=21.17，n P<0.01）和慢波睡眠（N3；分别为21.24%±4.12%、14.15%±6.08%、17.68%±6.35%，n F=29.51，n P<0.01）比例缩小，N1期（分别为4.47%±2.40%、9.50%±5.34%、9.55%±4.61%，n F=30.07，n P<0.05）和N2期（分别为53.88%±4.35%、64.09%±7.49%、58.14%±6.67%，n F=46.21，n P<0.05）睡眠比例增加，夜间平均血氧饱和度（SpOn 2）降低水平［分别为3.00%（0， 4.00%）、6.00%（5.00%， 8.75%）和4.00%（4.00%， 5.00%），n H=72.24，n P<0.05］、周期性腿动指数［分别为16.30（4.80， 32.82）、33.30（9.26， 54.80）和23.10（8.38， 31.83），n H=17.86，n P<0.05］、微觉醒指数［分别为11.60（7.73， 17.55）、23.90（14.03， 30.45）和15.6（11.23， 20.78），n H=22.80，n P<0.05］以及睡眠呼吸暂停和低通气指数（AHI，分别为1.60±1.38、23.90±7.27和16.24±4.22，n F=136.97，n P=0.000）升高。与单纯OSAHS组比，OSAHS合并PFO组中睡眠质量差者比例更高，慢波睡眠（N3，n F=29.51，n P=0.047）和快速眼球运动睡眠期（n F=21.17，n P=0.012）比例缩小，N2期睡眠比例（n F=46.21，n P=0.000）增加，夜间平均SpOn 2降低水平（n Z=54.28，n P=0.000）、入睡后觉醒时间［分别为116.00（89.88， 143.00）min和135.00（118.50， 168.38）min，Z=25.71，n P=0.023］、觉醒次数［分别为14.00（8.25， 8.00）和17.50（9.00，23.00），n Z=19.68，n P=0.041］增加，微觉醒指数（n Z=23.57，n P=0.044）、AHI（n F=136.97，n P=0.000）升高。n 结论:OSAHS合并PFO患者的睡眠质量差，夜间睡眠结构紊乱。其睡眠结构特点表现为睡眠效率降低，N2期睡眠延长，快速动眼睡眠期和慢波睡眠减少。PFO通过扰乱OSAHS的睡眠结构加重OSAHS的睡眠障碍程度。“,”Objective:To analyze the sleep quality and sleep structure of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with patent foramen ovale (PFO), and to study the effect of PFO on the sleep structure of OSAHS.Methods:Fifty-six patients with OSAHS complicated with PFO, 64 patients with simple OSAHS and 62 controls were collected from December 2018 to March 2020 in Centre of Sleep Disorders, the Second Affiliated Hospital of Zhengzhou University. Pittsburgh Sleep Quality Index and polysomnography were used to compare the sleep quality and sleep structure of the three groups.Results:Compared with the control group [6/62(9.68%)], OSAHS complicated with PFO group [54/56(96.43%)] and simple OSAHS group [53/64(82.81%)] had higher incidence of poor sleep quality (χ2=112.08,n P<0.0l). Furthermore, compared with the control group, the OSAHS complicated with PFO group and simple OSAHS group showed reduced sleep efficiency [PSQI total score was 0.5 (0, 1), 2 (1, 3) and 2 (1, 2) respectively,n H=74.549, n P<0.01] and reduced proportions of rapid eye movement (REM; 20.45%±3.49%, 12.19%±5.95% and 15.11%±7.21%,respectively,n F=21.17, n P<0.01) and slow wave sleep (N3; 21.24%±4.12%, 14.15%±6.08%, 17.68%±6.35%, respectively,n F=29.51, n P<0.01); the N1 (4.47%±2.40%, 9.50%±5.34%, 9.55%±4.61%, respectively,n F=30.07,n P<0.05) and N2 sleep (53.88%±4.35%, 64.09%±7.49%, 58.14%±6.67%n , respectively, n F=46.21,n P<0.05) were prolonged; the inocturnal lowest oxyhemoglobin saturation (SpOn 2) level was lower, mean SpOn 2 reduction at night was higher [3.00% (0, 4.00%),6.00% (5.00%, 8.75%) and 4.00% (4.00%, 5.00%), respectively, n H=72.24,n P<0.05], and periodic leg movement index [16.30(4.80, 32.82), 33.30(9.26, 54.80) and 23.10(8.38, 31.83),respectively,n H=17.86,n P<0.05], arousal index [11.60(7.73, 17.55), 23.90(14.03, 30.45) and 15.6(11.23, 20.78), respectively,n H=22.80, n P<0.05] and sleep apnea and hypopnea index (AHI; 1.60±1.38, 23.90±7.27 and 16.24±4.22,respectively,n F=136.97, n P<0.05) increased. Compared with the simple OSAHS group, the incidence of poor sleep quality was higher, the proportions of slow wave sleep (N3,n F=29.51, n P=0.047) and REM (n F=21.17, n P=0.012) were decreased, N2 sleep (n F=46.21, n P=0.000) was prolonged, mean SpOn 2 reduction at night (n Z=54.28, n P=0.000), wake after sleep onset [116.00(89.88, 143.00) min n vs 135.00(118.50, 168.38) min, n Z=25.71, n P=0.023], arousal times [14.00(8.25, 8.00) n vs 17.50(9.00,23.00),respectively, n Z=19.68, n P=0.041], microarousal (n Z=23.57, n P=0.044), and AHI (n F=136.97, n P=0.000) were increased in the OSAHS complicated with PFO group.n Conclusions:OSAHS complicated with PFO patients had poor sleep quality and high incidence of sleep disorders. They had sleep disorder at night, which was characterized by the decrease of REM sleep and slow wave sleep, the prolongation of N2, the decrease of nocturnal SpOn 2 and the increase of awakening times, and the increase of arousal times and AHI. PFO can aggravate the sleep disorder of OSAHS.n