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目的评价左旋卡尼汀联合葛根素在不稳定型心绞痛治疗中的效果以及安全情况。方法 90例不稳定型心绞痛患者作为研究对象,随机分为对照组和治疗组(每组各45例)。对照组患者应用硝酸酯类药物、阿司匹林、β受体阻滞剂等药物进行常规治疗,治疗组患者则在此基础上应用予葛根素400mg加入生理盐水250ml静脉滴注,左旋卡尼汀3.0g加入生理盐水250ml静脉滴注,均l次/d,疗程4周,对比两组疗效。结果治疗1个疗程4周后,治疗组总有效率为95.6%,对照组为77.8%,治疗组明显高于对照组(P﹤0.05)。治疗组和对照组的45例患者治疗1个疗程后,其心功能指标(LVEF)较治疗前明显提高,血脂指标(TC、TG)分别较治疗前明显降低(P﹤0.05),且与对照组比较,治疗组的上述指标改善较对照组更明显(P﹤0.05),差异有统计学意义,而HDL-C、LDL-C等指标治疗前后变化以及两组治疗后比较,差异无统计学意义(P﹥0.05)。治疗过程中两组患者均未发生明显不良反应。结论在不稳定型心绞痛治疗过程中联合应用左旋卡尼汀和葛根素,其治疗效果明显、无明显不良反应,可推广应用于该病的治疗。
Objective To evaluate the efficacy and safety of L-carnitine combined with puerarin in the treatment of unstable angina pectoris. Methods 90 patients with unstable angina pectoris were randomly divided into control group and treatment group (45 cases in each group). Patients in the control group were treated with nitrates, aspirin, β-blockers and other drugs for routine treatment. On the basis of this, patients in the treatment group were given puerarin 400mg intravenously with normal saline 250ml and levocarnitine 3.0g Add saline 250ml intravenous drip, were l times / d, the course of 4 weeks, the two groups compared efficacy. Results After one course of treatment for 4 weeks, the total effective rate was 95.6% in the treatment group and 77.8% in the control group, which was significantly higher in the treatment group than in the control group (P <0.05). After treatment for 1 course, 45 patients in the treatment group and the control group had significantly higher LVEF (LVEF) than before treatment, and the TC and TG were significantly lower than those before treatment (P <0.05) Compared with the control group, the improvement of the above indexes in the treatment group was more obvious (P <0.05), and the difference was statistically significant. However, there was no significant difference between the two groups in HDL-C, LDL-C and other indicators before and after treatment Significance (P> 0.05). No significant adverse reactions occurred in both groups during the course of treatment. Conclusions The combination of L-carnitine and puerarin in the treatment of unstable angina pectoris has obvious curative effect and no obvious adverse reactions, which can be widely used in the treatment of the disease.