论文部分内容阅读
目的探讨不同潮气量机械通气对大鼠膈肌放电的影响。方法将24只SD大鼠随机分为大潮气量组(10 m L/kg)、小潮气量组(5 m L/kg)和对照组。大潮气量组和小潮气量组大鼠进行不同潮气量的容量控制通气4 h,对照组麻醉后进行自主呼吸。在0、2、4 h分别测定大鼠膈肌放电情况,并监测血压、经皮血氧饱和度(Sp O_2)及呼气末二氧化碳分压(Pet CO_2),分析大鼠膈肌放电在不同潮气量和通气时长下的变化趋势以及Sp O_2、Pet CO_2与膈肌放电之间的关系。结果与对照组比较,大潮气量组膈肌放电频率降低,膈肌放电面积增大,膈肌放电振幅×膈肌放电频率(A×R)差异无统计学意义;而小潮气量组膈肌放电频率及膈肌放电面积无显著差异,仅膈肌放电振幅×膈肌放电频率(A×R)明显升高。Sp O_2在对照组及大潮气量组有所下降,Pet CO_2在大潮气量组也有所下降,其余各指标没有显著变化。结论不同潮气量机械通气对大鼠膈肌放电的影响不同,小潮气量机械通气可以兴奋呼吸中枢,增强膈肌放电,而大潮气量则表现为抑制效应。
Objective To investigate the effects of different tidal volume mechanical ventilation on diaphragm discharge in rats. Methods Twenty-four SD rats were randomly divided into two groups: large tidal volume (10 m L / kg), low tidal volume (5 m L / kg) and control group. Large tidal volume and low tidal volume of rats with different tidal volume of volume controlled ventilation 4 h, the control group after spontaneous breathing. At 0, 2 and 4 h, the discharge of diaphragm in rats was measured, and the blood pressure, Sp O 2 and Pet CO 2 were monitored. And ventilatory duration changes and the relationship between Sp O_2, Pet CO_2 and diaphragmatic discharge. Results Compared with the control group, the frequency of diaphragm discharge in the large tidal volume group was decreased, the area of diaphragm discharge was increased, and the amplitude of diaphragm discharge × the frequency of diaphragm discharge (A × R) was no significant difference. However, the frequency of diaphragm discharge and the area of diaphragm discharge Significant differences, only the amplitude of diaphragmatic discharge × diaphragmatic discharge frequency (A × R) was significantly increased. Sp O 2 decreased in the control group and the large tidal volume group, Pet CO 2 also decreased in the large tidal volume group, and the other indicators did not change significantly. Conclusion Different tidal volume mechanical ventilation has different effects on diaphragmatic discharge in rats. Low tidal volume mechanical ventilation can excite respiratory center, enhance diaphragmatic discharge, and large tidal volume show inhibitory effect.