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1983年Manson等首次提出了皮瓣缺血——再灌流损伤的自由基假说,认为皮瓣的坏死与缺血——再灌流过程中产生的自由基有关.根据这一新理论,人们对自由基引起皮瓣损伤的病理机制进行了大量研究,发
In 1983, Manson et al. First proposed the free radical hypothesis of flap ischemia-reperfusion injury and considered that the necrosis of the flap is related to the free radicals generated during ischemia-reperfusion. According to this new theory, A large number of studies have been conducted on the pathological mechanism of basement flap injury