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目的 :通过对临床人肺癌组织Na+/H+交换蛋白 1(NHE 1)mRNA的表达的检测 ,探讨肿瘤治疗新的特异靶点。方法 :采用RNA原位分子杂交法 (RNA IMH)检测了 2 7例人肺癌组织和正常肺组织NHE 1mRNA的表达。结果 :人肺癌组织细胞NHE 1mRNA的表达显著增强 ,呈过表达 ,而各病理类型间无显著差异。结论 :人肺癌组织细胞中NHE 1mRNA过表达这一区别于正常组织细胞的分子生物学特征与肿瘤细胞的抗凋亡特性的形成密切相关 ,可能为肿瘤治疗学提供良好的特异靶点并具有重要的潜在临床意义
Objective: To investigate the expression of NaE / H + 1 (NHE1) mRNA in clinical human lung cancer and to explore new target for tumor therapy. Methods: The expression of NHE 1 mRNA in 27 human lung cancer tissues and normal lung tissues was detected by RNA in situ hybridization (RNA IMH). Results: The expression of NHE-1 mRNA in human lung cancer cells was significantly increased and overexpressed, but no significant difference was found between the various pathological types. CONCLUSION: The molecular biological characteristics of NHE-1 overexpression in human lung cancer cells that are different from normal tissue cells are closely related to the formation of anti-apoptotic characteristics of tumor cells, which may provide a good specific target for tumor therapeutics and are important The potential clinical significance